DR F HEULE – THE NETHERLANDS
Dr F Heule, Professor of Dermatology at the Academic Hospital in Rotterdam, performed a twelve week double-blind placebo-controlled study on the effects of IMEDEEN on 46 women, aged between 40-65, all of whom had mild to moderate signs of photo-ageing. At the end of the period, Dr Heule observed that a number of parameters, including wrinkles, skin texture and dilated capillaries had improved significantly in the women taking IMEDEEN. Objective measurements on this group also showed an increase in skin thickness. Dr Heule concluded that IMEDEEN has a beneficial effect on signs of photo-ageing after twelve weeks of use

DR MARIANNE KIEFFER – DENMARK
The Danish dermatologist, Dr Marianne Kieffer, carried out a year long clinical study on the effects IMEDEEN on 144 women, aged between 35-50, all of whom had mild to moderate signs of photo-ageing. At the end of the study, a statistically significant improvement was shown in all the objective measuring tests, leading Dr Kieffer to conclude that IMEDEEN is active in the dermis where it improves basic skin structure and texture, as well as the skin’s natural ability to retain moisture. Over time, IMEDEEN can also help visibly reduce the appearance of fine lines and wrinkles, dilated capillaries and age spots, whilst improving the skin’s moisture balance.

“The concept of being able to improve the condition of the skin from within, instead of having to rely on skin creams, is both novel and logical. I like the idea that the skin cells are being nourished from the inside.”

DOCUMENTED RESULTS:
Heule F. An Oral Approach to the Treatment of Photodamaged Skin: a Pilot Study. The Journal of International Medical Research, 20 (1992) 273-278.

Heule F. The improvement of the consequences of cutaneous aging. Journal of the European Academy of Dermatology and Venereology, 3 (1994) 224

Kieffer ME and Efsen J. Imedeen®in the treatment of photoaged skin: an efficacy and safety trial over 12 months. Journal of the European Academy of Dermatology and Venereology, 11 (1998) 129-136.